Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

Matrix attachment regions (MARs) are cis-acting DNA elements that can increase transgene expression levels in a CHO cell expression system. To investigate the effects of MAR combinations on transgene expression and the underlying regulatory mechanisms, we generated constructs in which the enhanced g...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Zhao, Chun-Peng, Guo, Xiao, Chen, Si-Jia, Li, Chang-Zheng, Yang, Yun, Zhang, Jun-He, Chen, Shao-Nan, Jia, Yan-Long, Wang, Tian-Yun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316954/
https://ncbi.nlm.nih.gov/pubmed/28216629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42805
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