A chimeric HS4 insulator–scaffold attachment region enhances transgene expression in transfected Chinese hamster ovary cells

Chinese hamster ovary (CHO) cells are one of the most commonly used expression systems for the production of recombinant proteins but low levels of transgene expression and transgene silencing are frequently encountered. Epigenetic regulatory elements such as the chicken β‐globin locus control regio...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Chen, Si‐jia, Wang, Wen, Zhang, Feng‐yi, Jia, Yan‐long, Wang, Xiao‐yin, Guo, Xiao, Chen, Shao‐Nan, Gao, Jian‐hui, Wang, Tian‐Yun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715248/
https://ncbi.nlm.nih.gov/pubmed/29226088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12335
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