A chimeric HS4 insulator–scaffold attachment region enhances transgene expression in transfected Chinese hamster ovary cells

Chinese hamster ovary (CHO) cells are one of the most commonly used expression systems for the production of recombinant proteins but low levels of transgene expression and transgene silencing are frequently encountered. Epigenetic regulatory elements such as the chicken β‐globin locus control regio...

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Dettagli Bibliografici
Pubblicato in:FEBS Open Bio
Autori principali: Chen, Si‐jia, Wang, Wen, Zhang, Feng‐yi, Jia, Yan‐long, Wang, Xiao‐yin, Guo, Xiao, Chen, Shao‐Nan, Gao, Jian‐hui, Wang, Tian‐Yun
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Methods
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715248/
https://ncbi.nlm.nih.gov/pubmed/29226088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12335
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