Hypercholesterolemia in Progressive Renal Failure Is Associated with Changes in Hepatic Heparan Sulfate - PCSK9 Interaction

BACKGROUND: Dyslipidemia is an important risk factor in CKD. The liver clears triglyceride-rich lipoproteins (TRL) via LDL receptor (LDLR), LDLR-related protein-1 (LRP-1), and heparan sulfate proteoglycans (HSPGs), mostly syndecan-1. HSPGs also facilitate LDLR degradation by proprotein convertase su...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Shrestha, Pragyi, Adepu, Saritha, Vivès, Romain R., Masri, Rana El, Klooster, Astrid, Kaptein, Fleur, Dam, Wendy, Bakker, Stephan J. L., van Goor, Harry, van de Sluis, Bart, van den Born, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2021
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259657/
https://ncbi.nlm.nih.gov/pubmed/33758009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020091376
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