Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degradation of the LDL receptor (LDLR) in the liver and...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gustafsen, Camilla, Olsen, Ditte, Vilstrup, Joachim, Lund, Signe, Reinhardt, Anika, Wellner, Niels, Larsen, Torben, Andersen, Christian B. F., Weyer, Kathrin, Li, Jin-ping, Seeberger, Peter H., Thirup, Søren, Madsen, Peder, Glerup, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593881/
https://ncbi.nlm.nih.gov/pubmed/28894089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00568-7
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