Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

We examined the role of hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-loxP system, which resulted in an approximately 50% reduction in sulfation of liver heparan...

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Detalhes bibliográficos
Main Authors: MacArthur, Jennifer M., Bishop, Joseph R., Stanford, Kristin I., Wang, Lianchun, Bensadoun, André, Witztum, Joseph L., Esko, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716206/
https://ncbi.nlm.nih.gov/pubmed/17200715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29154
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