Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

We examined the role of hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-loxP system, which resulted in an approximately 50% reduction in sulfation of liver heparan...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: MacArthur, Jennifer M., Bishop, Joseph R., Stanford, Kristin I., Wang, Lianchun, Bensadoun, André, Witztum, Joseph L., Esko, Jeffrey D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2007
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716206/
https://ncbi.nlm.nih.gov/pubmed/17200715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29154
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы