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Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice

Elevated plasma triglyceride levels represent a risk factor for premature atherosclerosis. In mice, accumulation of triglyceride-rich lipoproteins can occur if sulfation of heparan sulfate in hepatocytes is diminished, as this alters hepatic lipoprotein clearance via heparan sulfate proteoglycans (H...

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Détails bibliographiques
Auteurs principaux: Stanford, Kristin I., Bishop, Joseph R., Foley, Erin M., Gonzales, Jon C., Niesman, Ingrid R., Witztum, Joseph L., Esko, Jeffrey D.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769193/
https://ncbi.nlm.nih.gov/pubmed/19805913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38251
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