Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

Properdin binds to proximal tubular epithelial cells (PTEC) and activates the complement system via the alternative pathway in vitro. Cellular ligands for properdin in the kidney have not yet been identified. Because properdin interacts with solid-phase heparin, we investigated whether heparan sulfa...

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Detalhes bibliográficos
Main Authors: Zaferani, Azadeh, Vivès, Romain R., van der Pol, Pieter, Hakvoort, Jelleke J., Navis, Gerjan J., van Goor, Harry, Daha, Mohamed R., Lortat-Jacob, Hugues, Seelen, Marc A., van den Born, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037648/
https://ncbi.nlm.nih.gov/pubmed/21135110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167825
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