Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

Properdin binds to proximal tubular epithelial cells (PTEC) and activates the complement system via the alternative pathway in vitro. Cellular ligands for properdin in the kidney have not yet been identified. Because properdin interacts with solid-phase heparin, we investigated whether heparan sulfa...

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Bibliografski detalji
Glavni autori: Zaferani, Azadeh, Vivès, Romain R., van der Pol, Pieter, Hakvoort, Jelleke J., Navis, Gerjan J., van Goor, Harry, Daha, Mohamed R., Lortat-Jacob, Hugues, Seelen, Marc A., van den Born, Jacob
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Glycobiology and Extracellular Matrices
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037648/
https://ncbi.nlm.nih.gov/pubmed/21135110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167825
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