Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate

During proteinuria, renal tubular epithelial cells become exposed to ultrafiltrate-derived serum proteins, including complement factors. Recently, we showed that properdin binds to tubular heparan sulfates (HS). We now document that factor H also binds to tubular HS, although to a different epitope...

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Bibliographic Details
Main Authors: Zaferani, Azadeh, Vivès, Romain R., van der Pol, Pieter, Navis, Gerjan J., Daha, Mohamed R., van Kooten, Cees, Lortat-Jacob, Hugues, Seelen, Marc A., van den Born, Jacob
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438980/
https://ncbi.nlm.nih.gov/pubmed/22815489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380386
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