Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can initiate the alternative complement pathway (...

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Pubblicato in:Front Immunol
Autori principali: Lammerts, Rosa G. M., Talsma, Ditmer T., Dam, Wendy A., Daha, Mohamed R., Seelen, Marc A. J., Berger, Stefan P., van den Born, Jacob
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426487/
https://ncbi.nlm.nih.gov/pubmed/32849563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01643
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