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Uncovering the molecular interactions in the catalytic loop that modulate the conformational dynamics in protein tyrosine phosphatase 1B

Active site loops are integral to the function of numerous enzymes, they enable substrate and product binding and release, sequester reaction intermediates, and recruit catalytic groups. Here, we examine the catalytic loop in the enzyme protein tyrosine phosphatase 1B (PTP1B). PTP1B has a mobile so-...

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Pubblicato in:J Am Chem Soc
Autori principali: Cui, Danica S., Lipchock, James Michael, Brookner, Dennis, Loria, J. Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259405/
https://ncbi.nlm.nih.gov/pubmed/31339043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04470
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