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Uncovering the molecular interactions in the catalytic loop that modulate the conformational dynamics in protein tyrosine phosphatase 1B

Active site loops are integral to the function of numerous enzymes, they enable substrate and product binding and release, sequester reaction intermediates, and recruit catalytic groups. Here, we examine the catalytic loop in the enzyme protein tyrosine phosphatase 1B (PTP1B). PTP1B has a mobile so-...

詳細記述

保存先:
書誌詳細
出版年:J Am Chem Soc
主要な著者: Cui, Danica S., Lipchock, James Michael, Brookner, Dennis, Loria, J. Patrick
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259405/
https://ncbi.nlm.nih.gov/pubmed/31339043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04470
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