טוען...
Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases
Drug-like molecules targeting allosteric sites in proteins are of great therapeutic interest; however, identification of potential sites is not trivial. A straightforward approach to identify hidden allosteric sites is demonstrated in protein tyrosine phosphatases (PTP) by creation of single alanine...
שמור ב:
| הוצא לאור ב: | J Mol Biol |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5549688/ https://ncbi.nlm.nih.gov/pubmed/28625849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.06.009 |
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