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CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment
GLI1 is one of three GLI family transcription factors that mediate Sonic Hedgehog signaling, which plays a role in development and cell differentiation. GLI1 forms a positive feedback loop with GLI2 and likely with itself. To determine the impact of GLI1 and its intronic regulatory locus on this tra...
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| 出版年: | Stem Cells |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley & Sons, Inc.
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8248124/ https://ncbi.nlm.nih.gov/pubmed/33497498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3341 |
| タグ: |
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