CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment

GLI1 is one of three GLI family transcription factors that mediate Sonic Hedgehog signaling, which plays a role in development and cell differentiation. GLI1 forms a positive feedback loop with GLI2 and likely with itself. To determine the impact of GLI1 and its intronic regulatory locus on this tra...

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Dettagli Bibliografici
Pubblicato in:Stem Cells
Autori principali: Galat, Yekaterina, Gu, Haigang, Perepitchka, Mariana, Taylor, Robert, Yoon, Joon Won, Glukhova, Xenia A., Li, Xiao‐Nan, Beletsky, Igor P., Walterhouse, David O., Galat, Vasiliy, Iannaccone, Philip M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2021
Soggetti:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248124/
https://ncbi.nlm.nih.gov/pubmed/33497498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3341
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