CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment

GLI1 is one of three GLI family transcription factors that mediate Sonic Hedgehog signaling, which plays a role in development and cell differentiation. GLI1 forms a positive feedback loop with GLI2 and likely with itself. To determine the impact of GLI1 and its intronic regulatory locus on this tra...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Galat, Yekaterina, Gu, Haigang, Perepitchka, Mariana, Taylor, Robert, Yoon, Joon Won, Glukhova, Xenia A., Li, Xiao‐Nan, Beletsky, Igor P., Walterhouse, David O., Galat, Vasiliy, Iannaccone, Philip M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2021
Assuntos:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248124/
https://ncbi.nlm.nih.gov/pubmed/33497498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3341
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