Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency

Ornithine transcarbamylase deficiency (OTCD) is a metabolic and genetic disease caused by dysfunction of the hepatocytic urea cycle. To develop new drugs or therapies for OTCD, it is ideal to use models that are more closely related to human metabolism and pathology. Primary human hepatocytes (HHs)...

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Vydáno v:J Inherit Metab Dis
Hlavní autoři: Sugahara, Go, Yamasaki, Chihiro, Yanagi, Ami, Furukawa, Suzue, Ogawa, Yuko, Fukuda, Akinari, Enosawa, Shin, Umezawa, Akihiro, Ishida, Yuji, Tateno, Chise
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2020
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247293/
https://ncbi.nlm.nih.gov/pubmed/33336822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12347
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