Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

Aflatoxin B1 (AFB1), a mycotoxin, is acutely hepatotoxic to many animals including humans. However, there are marked interspecies differences in sensitivity to AFB1-induced toxicity depending on bioactivation by cytochrome P450s (CYPs). In the present study, we examined the applicability of chimeric...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ishida, Yuji, Yamasaki, Chihiro, Iwanari, Hiroko, Yamashita, Hisahiko, Ogawa, Yuko, Yanagi, Ami, Furukawa, Suzue, Kojima, Yuha, Chayama, Kazuaki, Kamiie, Junichi, Tateno, Chise
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510964/
https://ncbi.nlm.nih.gov/pubmed/32966316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239540
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