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Characterization and applications of chimeric mice with humanized livers for preclinical drug development

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Lab Anim Res
Hauptverfasser: Tateno, Chise, Kojima, Yuha
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081693/
https://ncbi.nlm.nih.gov/pubmed/32206609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s42826-019-0032-y
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