Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers. However, uPA/SCID mice show four disadvantages: the human hepatocytes (h-heps) replacement index in mouse li...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Tateno, Chise, Kawase, Yosuke, Tobita, Yoshimi, Hamamura, Satoko, Ohshita, Hiroki, Yokomichi, Hiroshi, Sanada, Harumi, Kakuni, Masakazu, Shiota, Akira, Kojima, Yuha, Ishida, Yuji, Shitara, Hiroshi, Wada, Naoko A., Tateishi, Hiromi, Sudoh, Masayuki, Nagatsuka, Shin-ichiro, Jishage, Kou-ichi, Kohara, Michinori
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633119/
https://ncbi.nlm.nih.gov/pubmed/26536627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142145
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