Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency

Ornithine transcarbamylase deficiency (OTCD) is a metabolic and genetic disease caused by dysfunction of the hepatocytic urea cycle. To develop new drugs or therapies for OTCD, it is ideal to use models that are more closely related to human metabolism and pathology. Primary human hepatocytes (HHs)...

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Bibliografiske detaljer
Udgivet i:J Inherit Metab Dis
Main Authors: Sugahara, Go, Yamasaki, Chihiro, Yanagi, Ami, Furukawa, Suzue, Ogawa, Yuko, Fukuda, Akinari, Enosawa, Shin, Umezawa, Akihiro, Ishida, Yuji, Tateno, Chise
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2020
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247293/
https://ncbi.nlm.nih.gov/pubmed/33336822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12347
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