Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency

Ornithine transcarbamylase deficiency (OTCD) is a metabolic and genetic disease caused by dysfunction of the hepatocytic urea cycle. To develop new drugs or therapies for OTCD, it is ideal to use models that are more closely related to human metabolism and pathology. Primary human hepatocytes (HHs)...

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Bibliographische Detailangaben
Veröffentlicht in:J Inherit Metab Dis
Hauptverfasser: Sugahara, Go, Yamasaki, Chihiro, Yanagi, Ami, Furukawa, Suzue, Ogawa, Yuko, Fukuda, Akinari, Enosawa, Shin, Umezawa, Akihiro, Ishida, Yuji, Tateno, Chise
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247293/
https://ncbi.nlm.nih.gov/pubmed/33336822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12347
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