A Non-Affinity Purification Process for GMP Production of Prefusion-Closed HIV-1 Envelope Trimers from Clades A and C for Clinical Evaluation

Metastable glycosylated immunogens present challenges for GMP manufacturing. The HIV-1 envelope (Env) glycoprotein trimer is covered by N-linked glycan comprising half its mass and requires both trimer assembly and subunit cleavage to fold into a prefusion-closed conformation. This conformation, the...

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Bibliografiske detaljer
Udgivet i:Vaccine
Main Authors: Gulla, Krishana, Cibelli, Nicole, Cooper, Jonathan W., Fuller, Haley C., Schneiderman, Zachary, Witter, Sara, Zhang, Yaqiu, Changela, Anita, Geng, Hui, Hatcher, Christian, Narpala, Sandeep, Tsybovsky, Yaroslav, Zhang, Baoshan, McDermott, Adrian B., Kwong, Peter D., Gowetski, Daniel B.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8243839/
https://ncbi.nlm.nih.gov/pubmed/34020817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2021.04.063
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