A Non-Affinity Purification Process for GMP Production of Prefusion-Closed HIV-1 Envelope Trimers from Clades A and C for Clinical Evaluation

Metastable glycosylated immunogens present challenges for GMP manufacturing. The HIV-1 envelope (Env) glycoprotein trimer is covered by N-linked glycan comprising half its mass and requires both trimer assembly and subunit cleavage to fold into a prefusion-closed conformation. This conformation, the...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Gulla, Krishana, Cibelli, Nicole, Cooper, Jonathan W., Fuller, Haley C., Schneiderman, Zachary, Witter, Sara, Zhang, Yaqiu, Changela, Anita, Geng, Hui, Hatcher, Christian, Narpala, Sandeep, Tsybovsky, Yaroslav, Zhang, Baoshan, McDermott, Adrian B., Kwong, Peter D., Gowetski, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8243839/
https://ncbi.nlm.nih.gov/pubmed/34020817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2021.04.063
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