Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains

Soluble envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit neutralizing responses against HIV-1 strains closely related to the immunizing trimer. However, to date such stabilization has succeeded with only a limited number of HIV-1 strains. To address this issue, here...

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Foilsithe in:Cell Rep
Main Authors: Rawi, Reda, Rutten, Lucy, Lai, Yen-Ting, Olia, Adam S., Blokland, Sven, Juraszek, Jarek, Shen, Chen-Hsiang, Tsybovsky, Yaroslav, Verardi, Raffaello, Yang, Yongping, Zhang, Baoshan, Zhou, Tongqing, Chuang, Gwo-Yu, Kwong, Peter D., Langedijk, Johannes P.M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714614/
https://ncbi.nlm.nih.gov/pubmed/33238130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108432
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