A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

The heavily glycosylated native-like envelope (Env) trimer of HIV-1 is expected to have low immunogenicity, whereas misfolded forms are often highly immunogenic. High-quality correctly folded Envs may therefore be critical for developing a vaccine that induces broadly neutralizing antibodies. Moreov...

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Publicado en:Cell Rep
Autores principales: Rutten, Lucy, Lai, Yen-Ting, Blokland, Sven, Truan, Daphne, Bisschop, Ilona J.M., Strokappe, Nika M., Koornneef, Annemart, van Manen, Danielle, Chuang, Gwo-Yu, Farney, S. Katie, Schuitemaker, Hanneke, Kwong, Peter D., Langedijk, Johannes P.M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010203/
https://ncbi.nlm.nih.gov/pubmed/29642014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.061
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