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A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers
The heavily glycosylated native-like envelope (Env) trimer of HIV-1 is expected to have low immunogenicity, whereas misfolded forms are often highly immunogenic. High-quality correctly folded Envs may therefore be critical for developing a vaccine that induces broadly neutralizing antibodies. Moreov...
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| I publikationen: | Cell Rep |
|---|---|
| Huvudupphovsmän: | , , , , , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6010203/ https://ncbi.nlm.nih.gov/pubmed/29642014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.061 |
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