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iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis

Nucleotide-based drugs, such as antisense oligonucleotides (ASOs), have unique advantages in treating human diseases as they provide virtually unlimited ability to target any gene. However, their clinical translation faces many challenges, one of which is poor delivery to the target tissue in vivo....

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Podrobná bibliografie
Vydáno v:Adv Funct Mater
Hlavní autoři: Guan, Jibin, Guo, Hong, Tang, Tang, Wang, Yihan, Wei, Yushuang, Seth, Punit, Li, Yingming, Dehm, Scott M, Ruoslahti, Erkki, Pang, Hong-Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240484/
https://ncbi.nlm.nih.gov/pubmed/34211360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.202100478
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