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iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis

Nucleotide-based drugs, such as antisense oligonucleotides (ASOs), have unique advantages in treating human diseases as they provide virtually unlimited ability to target any gene. However, their clinical translation faces many challenges, one of which is poor delivery to the target tissue in vivo....

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Библиографические подробности
Опубликовано в: :Adv Funct Mater
Главные авторы: Guan, Jibin, Guo, Hong, Tang, Tang, Wang, Yihan, Wei, Yushuang, Seth, Punit, Li, Yingming, Dehm, Scott M, Ruoslahti, Erkki, Pang, Hong-Bo
Формат: Artigo
Язык:Inglês
Опубликовано: 2021
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240484/
https://ncbi.nlm.nih.gov/pubmed/34211360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.202100478
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