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iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis

Nucleotide-based drugs, such as antisense oligonucleotides (ASOs), have unique advantages in treating human diseases as they provide virtually unlimited ability to target any gene. However, their clinical translation faces many challenges, one of which is poor delivery to the target tissue in vivo....

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Bibliografske podrobnosti
izdano v:Adv Funct Mater
Main Authors: Guan, Jibin, Guo, Hong, Tang, Tang, Wang, Yihan, Wei, Yushuang, Seth, Punit, Li, Yingming, Dehm, Scott M, Ruoslahti, Erkki, Pang, Hong-Bo
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240484/
https://ncbi.nlm.nih.gov/pubmed/34211360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.202100478
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