Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency

Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules. MHCII deficiency results in impaired cellular and humoral immune respons...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Front Immunol
المؤلفون الرئيسيون: Ferrua, Francesca, Bortolomai, Ileana, Fontana, Elena, Di Silvestre, Dario, Rigoni, Rosita, Marcovecchio, Genni Enza, Draghici, Elena, Brambilla, Francesca, Castiello, Maria Carmina, Delfanti, Gloria, Moshous, Despina, Picard, Capucine, Taghon, Tom, Bordon, Victoria, Schulz, Ansgar S., Schuetz, Catharina, Giliani, Silvia, Soresina, Annarosa, Gennery, Andrew R., Signa, Sara, Dávila Saldaña, Blachy J., Delmonte, Ottavia M., Notarangelo, Luigi D., Roifman, Chaim M., Poliani, Pietro Luigi, Uva, Paolo, Mauri, Pier Luigi, Villa, Anna, Bosticardo, Marita
التنسيق: Artigo
اللغة:Inglês
منشور في: Frontiers Media S.A. 2021
الموضوعات:
Immunology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239840/
https://ncbi.nlm.nih.gov/pubmed/34211466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.669943
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