Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome

Thymocytes and thymic epithelial cell (TEC) cross-talk is crucial to preserve thymic architecture and function, including maturation of TECs and dendritic cells, and induction of mechanisms of central tolerance. We have analyzed thymic maturation and organization in 9 infants with various genetic de...

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Detalhes bibliográficos
Main Authors: Poliani, Pietro Luigi, Facchetti, Fabio, Ravanini, Maria, Gennery, Andrew Richard, Villa, Anna, Roifman, Chaim M., Notarangelo, Luigi D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710940/
https://ncbi.nlm.nih.gov/pubmed/19414857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-211029
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