Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications

Omenn syndrome (OS) is an atypical primary immunodeficiency characterized by severe autoimmunity because of activated T cells infiltrating target organs. The impaired recombinase activity in OS severely affects expression of the pre-T-cell receptor complex in immature thymocytes, which is crucial fo...

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Main Authors: Marrella, Veronica, Poliani, Pietro L., Fontana, Elena, Casati, Anna, Maina, Virginia, Cassani, Barbara, Ficara, Francesca, Cominelli, Manuela, Schena, Francesca, Paulis, Marianna, Traggiai, Elisabetta, Vezzoni, Paolo, Grassi, Fabio, Villa, Anna
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470012/
https://ncbi.nlm.nih.gov/pubmed/22723555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-406827
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