Abnormalities of Thymic Stroma may Contribute to Immune Dysregulation in Murine Models of Leaky Severe Combined Immunodeficiency

Lymphostromal cross-talk in the thymus is essential to allow generation of a diversified repertoire of T lymphocytes and to prevent autoimmunity by self-reactive T cells. Hypomorphic mutations in genes that control T cell development have been associated with immunodeficiency and immune dysregulatio...

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Detalhes bibliográficos
Main Authors: Rucci, Francesca, Poliani, Pietro Luigi, Caraffi, Stefano, Paganini, Tiziana, Fontana, Elena, Giliani, Silvia, Alt, Frederick W., Notarangelo, Luigi Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150116/
https://ncbi.nlm.nih.gov/pubmed/21822418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00015
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