Gene Modification and Three‐Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches

Defective functionality of thymic epithelial cells (TECs), due to genetic mutations or injuring causes, results in altered T‐cell development, leading to immunodeficiency or autoimmunity. These defects cannot be corrected by hematopoietic stem cell transplantation (HSCT), and thymus transplantation...

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發表在:Stem Cells Transl Med
Main Authors: Bortolomai, Ileana, Sandri, Monica, Draghici, Elena, Fontana, Elena, Campodoni, Elisabetta, Marcovecchio, Genni Enza, Ferrua, Francesca, Perani, Laura, Spinelli, Antonello, Canu, Tamara, Catucci, Marco, Di Tomaso, Tiziano, Sergi Sergi, Lucia, Esposito, Antonio, Lombardo, Angelo, Naldini, Luigi, Tampieri, Anna, Hollander, Georg A., Villa, Anna, Bosticardo, Marita
格式: Artigo
語言:Inglês
出版: John Wiley & Sons, Inc. 2019
主題:
Tissue Engineering and Regenerative Medicine
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766605/
https://ncbi.nlm.nih.gov/pubmed/31140762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.18-0218
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