Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome

Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by the defective expression of the WAS protein (WASP) in hematopoietic cells. It has been shown that dendritic cells (DCs) are functionally impaired in WAS patients and was(−/−) mice. We have previously demonstrated th...

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Hlavní autoři: Catucci, Marco, Prete, Francesca, Bosticardo, Marita, Castiello, Maria Carmina, Draghici, Elena, Locci, Michela, Roncarolo, Maria Grazia, Aiuti, Alessandro, Benvenuti, Federica, Villa, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378501/
https://ncbi.nlm.nih.gov/pubmed/22189416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.202
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