B-cell reconstitution after lentiviral vector–mediated gene therapy in patients with Wiskott-Aldrich syndrome

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a severe X-linked immunodeficiency characterized by microthrombocytopenia, eczema, recurrent infections, and susceptibility to autoimmunity and lymphomas. Hematopoietic stem cell transplantation is the treatment of choice; however, administration of WAS...

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Détails bibliographiques
Publié dans:J Allergy Clin Immunol
Auteurs principaux: Castiello, Maria Carmina, Scaramuzza, Samantha, Pala, Francesca, Ferrua, Francesca, Uva, Paolo, Brigida, Immacolata, Sereni, Lucia, van der Burg, Mirjam, Ottaviano, Giorgio, Albert, Michael H., Grazia Roncarolo, Maria, Naldini, Luigi, Aiuti, Alessandro, Villa, Anna, Bosticardo, Marita
Format: Artigo
Langue:Inglês
Publié: Mosby 2015
Sujets:
Immune Deficiencies, Infection, and Systemic Immune Disorders
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559137/
https://ncbi.nlm.nih.gov/pubmed/25792466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.01.035
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