B-cell reconstitution after lentiviral vector–mediated gene therapy in patients with Wiskott-Aldrich syndrome

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a severe X-linked immunodeficiency characterized by microthrombocytopenia, eczema, recurrent infections, and susceptibility to autoimmunity and lymphomas. Hematopoietic stem cell transplantation is the treatment of choice; however, administration of WAS...

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Vydáno v:J Allergy Clin Immunol
Hlavní autoři: Castiello, Maria Carmina, Scaramuzza, Samantha, Pala, Francesca, Ferrua, Francesca, Uva, Paolo, Brigida, Immacolata, Sereni, Lucia, van der Burg, Mirjam, Ottaviano, Giorgio, Albert, Michael H., Grazia Roncarolo, Maria, Naldini, Luigi, Aiuti, Alessandro, Villa, Anna, Bosticardo, Marita
Médium: Artigo
Jazyk:Inglês
Vydáno: Mosby 2015
Témata:
Immune Deficiencies, Infection, and Systemic Immune Disorders
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559137/
https://ncbi.nlm.nih.gov/pubmed/25792466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.01.035
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