Wird geladen...
Human DNA polymerase θ harbors a DNA end-trimming activity critical for DNA repair
Cancers with hereditary defects in homologous recombination rely on DNA polymerase θ (pol θ) for repair of DNA double-strand breaks. During end-joining, pol θ aligns microhomology tracts internal to 5′-resected broken ends, after which an unidentified nuclease trims the 3′-end before synthesis can o...
Gespeichert in:
| Veröffentlicht in: | Mol Cell |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8231307/ https://ncbi.nlm.nih.gov/pubmed/33577776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.021 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|