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Expression and Structural Analyses of Human DNA polymerase θ (POLQ)

DNA polymerase theta (pol θ) is an evolutionarily conserved protein encoded by the POLQ gene in mammalian genomes. Pol θ is the defining enzyme for a pathway of DSB repair termed “alternative end-joining” (altEJ) or “theta-mediated end-joining”. This pathway contributes significantly to the radiatio...

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Publicat a:Methods Enzymol
Autors principals: Malaby, Andrew W., Martin, Sara K., Wood, Richard D., Doublié, Sylvie
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624038/
https://ncbi.nlm.nih.gov/pubmed/28668117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2017.03.026
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