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Human DNA polymerase θ harbors a DNA end-trimming activity critical for DNA repair
Cancers with hereditary defects in homologous recombination rely on DNA polymerase θ (pol θ) for repair of DNA double-strand breaks. During end-joining, pol θ aligns microhomology tracts internal to 5′-resected broken ends, after which an unidentified nuclease trims the 3′-end before synthesis can o...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8231307/ https://ncbi.nlm.nih.gov/pubmed/33577776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.021 |
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