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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
DNA polymerase θ protects against genomic instability via an alternative end-joining repair pathway for DNA double-strand breaks. Breast, lung and oral cancers over-express polymerase θ, and reduction of its activity in mammalian cells increases sensitivity to double-strand break inducing agents, in...
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| Gepubliceerd in: | Nat Struct Mol Biol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4385486/ https://ncbi.nlm.nih.gov/pubmed/25775267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2993 |
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