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The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ
DNA polymerase θ (Pol θ) is implicated in various cellular processes including double-strand break repair and apurinic/apyrimidinic site bypass. Because Pol θ expression correlates with poor cancer prognosis, the ability of Pol θ to bypass the C4′-oxidized abasic site (C4-AP) and 2-deoxyribonolacton...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499511/ https://ncbi.nlm.nih.gov/pubmed/28459528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00211 |
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