Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism

In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the findings from off-target screening, resulted in the...

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Vydáno v:Biomedicines
Hlavní autoři: Lee, Yeon Sun, Remesic, Michael, Ramos-Colon, Cyf, Wu, Zhijun, LaVigne, Justin, Molnar, Gabriella, Tymecka, Dagmara, Misicka, Aleksandra, Streicher, John M., Hruby, Victor J., Porreca, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229567/
https://ncbi.nlm.nih.gov/pubmed/34072734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9060625
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