Design and Synthesis of Novel Bivalent Ligands (MOR and DOR) by Conjugation of Enkephalin Analogues with 4-Anilidopiperidine Derivatives

We describe the design and synthesis of novel bivalent ligands based on the conjugation of 4-anilidopiperidine derivatives with enkephalin analogues. The design of non-peptide analogues is explored with 5-amino substituted tetrahydronaphthalen-2yl)methyl containing 4-anilidopiperidine derivatives, w...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Deekonda, Srinivas, Wugalter, Lauren, Rankin, David, Largent-Milnes, Tally M., Davis, Peg, Wang, Yue, Bassirirad, Neemah M., Lai, Josephine, Kulkarni, Vinod, Vanderah, Todd W., Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642889/
https://ncbi.nlm.nih.gov/pubmed/26323872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.07.064
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