Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy µ-Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities

In a previously described peptidomimetic series, we reported the development of bifunctional µ-opioid receptor (MOR) agonist and δ-opioid receptor (DOR) antagonist ligands with a lead compound that produced antinociception for 1 h after intraperitoneal administration in mice. In this paper, we expan...

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Pubblicato in:J Med Chem
Autori principali: Harland, Aubrie A., Yeomans, Larisa, Griggs, Nicholas W., Anand, Jessica P., Pogozheva, Irina D., Jutkiewicz, Emily M., Traynor, John R., Mosberg, Henry I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772774/
https://ncbi.nlm.nih.gov/pubmed/26524472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01270
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