Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability

We have previously reported a series of μ-opioid receptor (MOR) agonist/ δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active in vivo, do not manifest withdrawal syndromes or reward behavior in conditioned-place p...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Henry, Sean P., Fernandez, Thomas J., Anand, Jessica P., Griggs, Nicholas W., Traynor, John R., Mosberg, Henry I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713576/
https://ncbi.nlm.nih.gov/pubmed/30924650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00219
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items