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Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability
We have previously reported a series of μ-opioid receptor (MOR) agonist/ δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active in vivo, do not manifest withdrawal syndromes or reward behavior in conditioned-place p...
Tallennettuna:
| Julkaisussa: | J Med Chem |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6713576/ https://ncbi.nlm.nih.gov/pubmed/30924650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00219 |
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