Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability

We have previously reported a series of μ-opioid receptor (MOR) agonist/ δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active in vivo, do not manifest withdrawal syndromes or reward behavior in conditioned-place p...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Henry, Sean P., Fernandez, Thomas J., Anand, Jessica P., Griggs, Nicholas W., Traynor, John R., Mosberg, Henry I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713576/
https://ncbi.nlm.nih.gov/pubmed/30924650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00219
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