In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment. Although, it is known the action spectrum of both compounds affect the Leishmania spp. multiplication, there are gaps in the molecular bindi...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Peixoto, Juliana Figueiredo, Oliveira, Adriane da Silva, Monteiro, Patrícia Queiroz, Gonçalves-Oliveira, Luiz Filipe, Andrade-Neto, Valter Viana, Ferreira, Vitor Francisco, Souza-Silva, Franklin, Alves, Carlos Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229338/
https://ncbi.nlm.nih.gov/pubmed/34200517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26123537
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