In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment. Although, it is known the action spectrum of both compounds affect the Leishmania spp. multiplication, there are gaps in the molecular bindi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Peixoto, Juliana Figueiredo, Oliveira, Adriane da Silva, Monteiro, Patrícia Queiroz, Gonçalves-Oliveira, Luiz Filipe, Andrade-Neto, Valter Viana, Ferreira, Vitor Francisco, Souza-Silva, Franklin, Alves, Carlos Roberto
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
Sujets:
Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229338/
https://ncbi.nlm.nih.gov/pubmed/34200517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26123537
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