The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis

Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs. In this study we analyzed the potential of the associat...

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Detalhes bibliográficos
Publicado no:Int J Parasitol Drugs Drug Resist
Main Authors: Gonçalves-Oliveira, Luiz Filipe, Souza-Silva, Franklin, de Castro Côrtes, Luzia Monteiro, Veloso, Laura Barral, Santini Pereira, Bernardo Acácio, Cysne-Finkelstein, Lea, Lechuga, Guilherme Curty, Bourguignon, Saulo Cabral, Almeida-Souza, Fernando, da Silva Calabrese, Kátia, Ferreira, Vitor Francisco, Alves, Carlos Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712286/
https://ncbi.nlm.nih.gov/pubmed/31430693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2019.08.002
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