In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment. Although, it is known the action spectrum of both compounds affect the Leishmania spp. multiplication, there are gaps in the molecular bindi...

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Publicat a:Molecules
Autors principals: Peixoto, Juliana Figueiredo, Oliveira, Adriane da Silva, Monteiro, Patrícia Queiroz, Gonçalves-Oliveira, Luiz Filipe, Andrade-Neto, Valter Viana, Ferreira, Vitor Francisco, Souza-Silva, Franklin, Alves, Carlos Roberto
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
Matèries:
Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229338/
https://ncbi.nlm.nih.gov/pubmed/34200517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26123537
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