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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1’s function is well established in DNA double-strand break repair, how its role in p53 signaling is modulated remains poorly understood. Here, we identify the scaffolding protein AHNAK as a G1 phase...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cell Press
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8221568/ https://ncbi.nlm.nih.gov/pubmed/33961796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.010 |
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