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Phase separation of 53BP1 determines liquid‐like behavior of DNA repair compartments

The DNA damage response (DDR) generates transient repair compartments to concentrate repair proteins and activate signaling factors. The physicochemical properties of these spatially confined compartments and their function remain poorly understood. Here, we establish, based on live cell microscopy...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Kilic, Sinan, Lezaja, Aleksandra, Gatti, Marco, Bianco, Eliana, Michelena, Jone, Imhof, Ralph, Altmeyer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694294/
https://ncbi.nlm.nih.gov/pubmed/31267591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018101379
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